In Shinjuku ward's east side lies Kabukichou, a vibrant city of chaos that glows brilliantly with neon lights but also hides unseen darkness. Employed at a university hospital on the west side, John H. Watson is looking for someone who can assist him with an odd case. His search leads him to the Pipe Cat, an underground bar that serves as a meetup venue and job board for some of the best detectives in Shinjuku, the most prominent among them being Sherlock Holmes. Upon finding the bar and meeting the peculiar investigators, John learns that they are pursuing a case involving Jack the Ripper, an infamous serial killer. Due to subsequent events, John ends up driving Sherlock to the crime scene of a murder supposedly carried out by Jack the Ripper. Even though John is only there to enlist Sherlock's help with his case, he witnesses Sherlock brilliantly uncover the truth behind the crime scene. However, he begins to realize that Sherlock is not only a genius detective but also an eccentric character. As John continues to request Sherlock to assist him with his case, he finds himself spiraling into the detective lifestyle of solving cases beyond the minds of ordinary civilians. Through this work, John begins to see the true colors of the chaotic city that is Kabukichou and starts to unravel the unsettling mystery behind his own case.

Drugs have become the center of conflict in Japan, and crime involving them has been increasing at an alarming rate. Unable to control the chaos, the police department settled on creating a unit—STAND—that would include unique, specialized experts and professionals better suited to handle the pressing issue. Rei Izumi is a novice joining the narcotics investigation unit, assigned the daunting task of recruiting the potential representatives of STAND. While recommended for her moral sense of justice and devotion to police work, Rei also has a unique aspect of her own that may have earned her the job—she has an immunity to many, if not most, kinds of drugs. Eager to seek the possible members of STAND, Rei quickly learns that scouting the different individuals will be more difficult than she expected, as each candidate harbors their own feelings, ideologies, and willingness toward joining the team and regulating drugs as a whole. Her capability as a narcotics officer is also questioned by the many colorful personalities she meets, stirring conflict and unpredictability in Rei's daily life. However, persuading the various contenders for STAND isn't the only obstacle she faces, as becoming involved in the treacherous underworld of drugs, overflowing with deceit and secrecy, will be more hazardous than she ever imagined.

Thanks to the Sibyl System, the mental states of society can now be measured on a numerical scale. Using these "crime coefficients," a culprit can be apprehended before they ever commit a crime. But is it a perfect system? For Inspectors Kei Mikhail Ignatov and Arata Shindou, that remains to be seen, as their career with the Public Safety Bureau's Crime Investigation Department has only just begun. Shindou and Ignatov are assigned to investigate the crash of a ship carrying immigrants, but they begin to suspect that it was no mere accident. Meanwhile, a mysterious group called Bifrost is observing them from the shadows, but they are not the only ones who have taken an interest in the two new Inspectors.

A ghost was seen on the 12th floor of the Asakusa Juunikai building. A newspaper article featuring the sighting brought together Takuboku Ishikawa, who runs a private detective agency to support his family, and his assistant Kyosuke Kindaichi to solve the case. (Source: MAL News)